Immunoproteomic analysis of outer membrane proteins and extracellular proteins of Actinobacillus pleuropneumoniae JL03 serotype 3

Immunoproteomic analysis of outer membrane proteins and extracellular proteins of Actinobacillus pleuropneumoniae JL03 serotype 3

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Abstract Background Actinobacillus pleuropneumoniae is the causative agent of porcine contagious pleuropneumonia, a highly contagious respiratory infection in pigs, and all the 15 serotypes are able to cause disease.Current vaccines including subunit vaccines could not provide satisfactory protection against A.pleuropneumoniae.In this study, the immunoproteomic approach was applied to the analysis of extracellular and outer membrane proteins of A.pleuropneumoniae JL03 serotype 3 for what is quadruple topical ointment used for the identification of novel immunogenic proteins for A.

pleuropneumoniae.Results am22 pro model A total of 30 immunogenic proteins were identified from outer membrane and extracellular proteins of JL03 serotype 3, of which 6 were known antigens and 24 were novel immunogenic proteins for A.pleuropneumoniae.Conclusion These data provide information about novel immunogenic proteins for A.pleuropneumoniae serotype 3, and are expected to aid in development of novel vaccines against A.

pleuropneumoniae.